De novo is an industry term for branches built from scratch instead of being acquired fully developed from another bank. Issuing the manual publicly will provide transparency and benefit applicants and other interested parties by further clarifying the path to establishing a de novo institution. De novo synthesis is a unique phase in the transcription cycle where the RNA polymerase binds two nucleotides rather than a nascent RNA polymer and a single nucleotide. Find out what does de novo mean in medical terms, from genetics and pharmacology to clinical conditions. Explore its meaning, implications, and examples in medicine. De novo means “from the beginning” in cancer contexts, covering metastatic spread, mutations, and drug resistance from the start of diagnosis. Learn what does de novo mean in healthcare, from spontaneous genetic mutations to the FDA's approval pathway for innovative medical devices. Understand its significance across different medical contexts. NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. In biology, for instance, de novo describes some biological process or entity that has begun again. It is a phrase that roughly translates to “new” or “anew”. The same meaning applies to medical and other related fields. Some people italicize the term to indicate that it is a Latin phrase.